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Presents
the Friday Keck Center Teleconference*
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Systems
Biology of Cellular Phenotypes: Computational Modeling of
Pathways.
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Shankar
Subramaniam, Ph.D.,
Department
of Bioengineering, Department of Chemistry & Biochemistry
San
Diego Supercomputing Center, University of California at San Diego
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4:00
pm Friday
28th
April, 2006
(Refreshments
at 3:45)
5.521
Levin Hall
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Abstract:
Systems biology approaches to understanding eukaryotic cell
function have enabled painstaking reconstruction of intracellular
networks that map input to response. However, quantitative
modeling of these networks continues to remain a challenge owing
to both unavailability of myriad parameters and concentrations of
species in the network. Using a well-studied example, I will
discuss the challenges in quantitative modeling of networks and
discuss its implications for experimental biology. I will then
discuss new strategies for coarse-grained quantitative modeling.
Coarse-grained biochemical models, called reduced-order models
(ROM), consisting of essential biochemical mechanisms are more
useful for computational analysis and for studying important
features of a biochemical network. I will discuss applications of
ROM for a simple and a very complex biochemical network and
illustrate how this modeling can lead to systems level hypothesis
generation and understanding of cellular biology.
(
http://www-bioeng.ucsd.edu/research/research_groups/compbio/shankar.html
).
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The
Keck Friday Seminar*
schedule
for SPRING 2006
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13-Jan
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Elmer
Bernstam, UTHSC-H
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Consumer
Health Information on the Internet: Whose problem is it?
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20-Jan
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Leo
Linbeck III, AlphaDev
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From
Translational Research to Spin-Offs: Challenges, Issues and
Solutions
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27-Jan
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Michael
Roth, UT Southwestern Medical School
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High-throughput
Screening of Chemical Compound and Genomic RNAi Libraries in an
Academic Setting.
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3-Feb
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Scott
Perry, Asso. Professor, Chemistry, Univ. of Houston
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Biomimetic
Lubrication Schemes: Slippery When Wet.
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10-Feb
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Jim
Briggs, UH
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Dynamics
and Inhibition of Botulinum Neurotoxins.
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17-Feb
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Rebekah
Drezek, Rice University
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Establishing
a New Biomedical Research Lab: The First Three (and a Half) Years.
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24-Feb
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M.
Neal Waxham, UTHSC-H
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Biophysical
Techniques to Explore Intracellular Signaling Pathways in vitro
and in situ.
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3-Mar
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Stephen
H. Bryant, NLM
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Protein
Classification Methods for NCBI's Conserved Domain Database
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10-Mar
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Vibhu
Mittal, Sr. Res. Scientist, Google
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Searching
Scholarly Stuff
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17-Mar
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No
Seminar –
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Spring
Break
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24-Mar
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Tony
Gorry, RICE
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Information
Technology and Behavior
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31-Mar
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Theresa
M. Koehler, UTHSC-H
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Regulation
of Bacillus anthracis Virulence Gene Expression and Implications
for the Host.
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7-Apr
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Alasdair
Steven, NIAMS/NIH
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Observing
the Structural Variability of Viruses in Space and Time.
***LIVE FROM UTMB
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14-Apr
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No
Seminar –
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Good
Friday
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21-Apr
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Hualou
Liang, UTHSC-H
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The
Role of Synchronized Activity during Anticipation of Visuomotor
Processing
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28-Apr
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Shankar
Subramaniam, SDSC,UCSD
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Systems
Biology of Cellular Phenotypes: Computational Modeling of Pathways
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5-May
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Joan-Emma
Shea, UCSB
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TBA
- Protein Folding
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KECK/HAMP
Friday Seminars: http://xray.utmb.edu/keck
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Archived
Friday Seminar Webcasts Available:
http://cohesion.rice.edu/centersandinst/gcc/
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*Improved
clearer images: Now with POLYCOM's
DUAL STREAMING H.239 technology for clear
high-resolution slides plus video.
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