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Presents
the Friday Keck Center Teleconference*
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Simulations
of the Self-Assembly of the Alzheimer Amyloid-beta Peptide.
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Joan-Emma
Shea, Ph.D.,
Assistant
Professor, Department of Chemistry and Biochemistry
and
the California Nanosystems Institute, University of California at
Santa Barbara
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4:00
pm Friday
5th
May, 2006
(Refreshments
at 3:45)
5.521
Levin Hall
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Abstract: Alzheimer’s
disease is a debilitating neurodegenerative disorder associated
with the abnormal self-assembly of the Alzheimer Amyloid-beta (Ab)
peptide into fibrillar species. An attractive therapeutic
approach to combat amyloid diseases lies in the development of
strategies to inhibit or reverse aggregation. In the first part of
my talk, I will present molecular dynamics simulations of the
early stages of aggregation of the Ab peptide. In the second part,
I will discuss simulations of the inhibition of Ab fibrillogenesis
by N-methylated peptides homologous to the central hydrophobic
core of the Ab peptide.
(
http://www.chem.ucsb.edu/%7Esheagroup/research/
).
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The
Keck Friday Seminar*
schedule
for SPRING 2006
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13-Jan
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Elmer
Bernstam, UTHSC-H
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Consumer
Health Information on the Internet: Whose problem is it?
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20-Jan
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Leo
Linbeck III, AlphaDev
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From
Translational Research to Spin-Offs: Challenges, Issues and
Solutions
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27-Jan
|
Michael
Roth, UT Southwestern Medical School
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High-throughput
Screening of Chemical Compound and Genomic RNAi Libraries in an
Academic Setting.
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3-Feb
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Scott
Perry, Asso. Professor, Chemistry, Univ. of Houston
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Biomimetic
Lubrication Schemes: Slippery When Wet.
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10-Feb
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Jim
Briggs, UH
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Dynamics
and Inhibition of Botulinum Neurotoxins.
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17-Feb
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Rebekah
Drezek, Rice University
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Establishing
a New Biomedical Research Lab: The First Three (and a Half) Years.
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24-Feb
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M.
Neal Waxham, UTHSC-H
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Biophysical
Techniques to Explore Intracellular Signaling Pathways in vitro
and in situ.
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3-Mar
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Stephen
H. Bryant, NLM
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Protein
Classification Methods for NCBI's Conserved Domain Database
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10-Mar
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Vibhu
Mittal, Sr. Res. Scientist, Google
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Searching
Scholarly Stuff
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17-Mar
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No
Seminar –
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Spring
Break
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24-Mar
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Tony
Gorry, RICE
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Information
Technology and Behavior
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31-Mar
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Theresa
M. Koehler, UTHSC-H
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Regulation
of Bacillus anthracis Virulence Gene Expression and Implications
for the Host.
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7-Apr
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Alasdair
Steven, NIAMS/NIH
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Observing
the Structural Variability of Viruses in Space and Time.
***LIVE FROM UTMB
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14-Apr
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No
Seminar –
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Good
Friday
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21-Apr
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Hualou
Liang, UTHSC-H
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The
Role of Synchronized Activity during Anticipation of Visuomotor
Processing
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28-Apr
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Shankar
Subramaniam, SDSC,UCSD
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Systems
Biology of Cellular Phenotypes: Computational Modeling of Pathways
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5-May
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Joan-Emma
Shea, UCSB
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Simulations
of the Self-Assembly of the Alzheimer Amyloid-beta Peptide
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KECK/HAMP
Friday Seminars: http://xray.utmb.edu/keck
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Archived
Friday Seminar Webcasts Available:
http://cohesion.rice.edu/centersandinst/gcc/
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*Improved
clearer images: Now with POLYCOM's
DUAL STREAMING H.239 technology for clear
high-resolution slides plus video.
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