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Presents
the Friday Keck Center Teleconference*
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Conformational
Regulation and Electrostatics of the Nicotine Acetylcholine
Receptor.
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Steen
Pedersen, Ph.D.,
Associate
Professor, BCM, Dept. of Physiology and Biophysics
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4:00
pm Friday
8th
Sept. , 2006
(Refreshments
at 3:45)
5.521
Levin Hall
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Abstract: The
nicotinic acetylcholine receptor mediates rapid neurotransmission
at the neuromuscular junction and other sites within the central
and peripheral nervous system. Reliable, fast channel response to
the binding of acetylcholine is critical for proper functioning.
Kinetic measurements of binding to the acetylcholine sites show
two-fold enhancements in association rate in agreement with the
potential measurements. At the ion channel, however, computed
potentials over-estimated the measured potentials substantially.
This suggests a need for improved experimentation or computation
to understand electrostatic interactions within the confines of
ion channels. Further kinetic measurements reveal that binding
regulates opening and subsequent desensitization of the channel
predominantly through one of the two binding sites, the
alpha-gamma site. (
http://www.bcm.edu/physio/faculty/pedersen/pedersen.html
)
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The
Keck Friday Seminar*
schedule
for Fall 2006
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25-Aug
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Monte Pettitt, Chair,
KEC, Professor, Dept. of Chemistry, UH
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Overview of
Keck Center and GCC (5.520 Levin
Hall)
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1-Sept
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Labor
Day Weekend
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8-Sept
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Dr. Steen Pedersen,
Assoc. Professor, BCM, Dept. of Physiology and Biophysics
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Conformational
Regulation and Electrostatics of the Nicotine Acetylcholine
Receptor
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15-Sept
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Dr. C. J. Peters, M.D.,
Professor, Director for Biodefense, Center
for Biodefense and Emerging Infectious Diseases, UTMB
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TBA.
***LIVE
FROM UTMB
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22-Sept
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TBA
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(5.520
Levin Hall)
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29-Sept
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Dr. James Inglese, Dir,
Biomolocular Screening & Profiling, NIH, Nat’l Human Genome
Research Institute, Chemical Genomics Center
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Quantitative
High Throughput Screening: Discovery of Investigational Molecular
Probes through the Biological Activity Profiling of Chemical
Libraries
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6-Oct
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TBA
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TBA
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13-Oct
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Keck
Annual Research Conference
https://cohesion.rice.edu/services/eventreg/?event=ARC6
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Edwin
Hornberger Conference Center, Texas Medical Center
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20-Oct
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Marek Kimmel,
Professor, Statistics, Rice
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TBA
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27-Oct
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TBA
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(5.520
Levin Hall)
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3-Nov
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CMB/SCBMB
Retreat
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10-Nov
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TBA
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TBA
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17-Nov
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Rigoberto Advincula,
Assoc. Prof, Chemistry, UH
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TBA
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24-Nov
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Thanksgiving
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1-Dec
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Ruth Nussinov, Sr.
Prin. Scien, Nat’l Cancer Institute, Center for Cancer Res,
Computational Structural Biology Group
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TBA
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KECK/HAMP
Friday Seminars: http://xray.utmb.edu/keck
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Archived
Friday Seminar Webcasts Available:
http://cohesion.rice.edu/centersandinst/gcc/
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*Improved
clearer images: Now with POLYCOM's
DUAL STREAMING H.239 technology for clear
high-resolution slides plus video.
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