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Presents
the Friday Keck Center Teleconference*
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Single
Molecule Studies of Disease-related Biological Processes:
HIV
reverse transcription and herpes virus infection
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Christy
Landes, Ph.D.,
Assistant
Professor of Chemistry,
University
of Houston
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4:00
pm Friday
17th
Nov. , 2006
(Refreshments
at 3:45)
5.521
Levin Hall
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Abstract: Single
molecule fluorescence resonance energy transfer (SMFRET) has been
used to characterize the nucleocapsid protein- chaperoned
minus-strand transfer step that occurs during HIV-1 reverse
transcription. The technique has allowed us to classify bond
formation and nucleic acid structure involved in HIV-1 reverse
transcription with unprecedented resolution. The single molecule
results reveal two competing annealing pathways, a conclusion
obscured by alternate ensemble techniques. We also have measured
protein-induced nucleic acid structural dynamics associated with
chaperoning the preferred annealing pathway. Finally, the
resolving power of SMFRET has been used to characterize a model
reverse transcription inhibitor, which was found to be successful
against only one of the two annealing pathways. Such
molecular-level detail in drug efficacy analysis could help us to
rectify the inefficiency of current therapeutic options caused by
rapid viral mutation and multiple reaction pathways.
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The
Keck Friday Seminar*
schedule
for Fall 2006
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25-Aug
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Monte Pettitt, Chair,
KEC, Professor, Dept. of Chemistry, UH
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Overview of
Keck Center and GCC (5.520 Levin
Hall)
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1-Sept
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Labor
Day Weekend
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8-Sept
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Dr. Steen Pedersen,
Assoc. Professor, BCM, Dept. of Physiology and Biophysics
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Conformational
Regulation and Electrostatics of the Nicotine Acetylcholine
Receptor
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15-Sept
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Dr. C. J. Peters, M.D.,
Professor, Director for Biodefense, Center
for Biodefense and Emerging Infectious Diseases, UTMB
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Rift
Valley Fever: Adventures in Control and Vaccine Development.
***LIVE
FROM UTMB
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22-Sept
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Jacqueline
Northcut Waugh
President
and CEO,
BioHouston
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Reaching
for critical mass in Biotech (5.520
Levin Hall)
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29-Sept
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Dr. James Inglese, Dir,
Biomolocular Screening & Profiling, NIH, Nat’l Human Genome
Research Institute, Chemical Genomics Center
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Quantitative
High Throughput Screening: Discovery of Investigational Molecular
Probes through the Biological Activity Profiling of Chemical
Libraries
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6-Oct
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Luay
Nakhleh
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Non-treelike
Evolutionary Relationships
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13-Oct
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Keck
Annual Research Conference
https://cohesion.rice.edu/services/eventreg/?event=ARC6
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Edwin
Hornberger Conference Center, Texas Medical Center
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20-Oct
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ACS
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27-Oct
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Misha
Sherman, UTMB
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CryoEM
at UTMB ***LIVE
FROM UTMB
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3-Nov
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Marek
Kimmel, Professor, Statistics, Rice
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TBA
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10-Nov
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Ken Kennedy, Professor,
Rice University
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Software
Support for Development of Scientific Applications for the Grid
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17-Nov
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Christy
Landes, Assistant Professor, Chemistry, University of Houston
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Single
molecule studies of disease-related biological processes: HIV
reverse transcription and herpes virus infection
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24-Nov
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Thanksgiving
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1-Dec
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Ruth Nussinov, Sr.
Prin. Scien, Nat’l Cancer Institute, Center for Cancer Res,
Computational Structural Biology Group
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TBA
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KECK/HAMP
Friday Seminars: http://xray.utmb.edu/keck
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Archived
Friday Seminar Webcasts Available:
http://cohesion.rice.edu/centersandinst/gcc/
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*Improved
clearer images: Now with POLYCOM's
DUAL STREAMING H.239 technology for clear
high-resolution slides plus video.
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