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Presents
the Friday Keck Center Teleconference*
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Structure
by Design:
from
single proteins and their building blocks to nanostructures
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Ruth
Nussinov, Ph.D.,
Senior
Principal Scientist, Center for Cancer Research,
Computational
Structural Biology Group, National Cancer Institute
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4:00
pm Friday
1st
Dec. , 2006
(Refreshments
at 3:45)
5.521
Levin Hall
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Abstract:
Nanotechnology realizes the advantages of naturally occurring
biological macromolecules and their building- block nature for
design. Frequently, assembly starts with the choice of a "good"
molecule that is synthetically optimized towards the desired
shape. By contrast, we propose starting with a pre-specified
nanostructure shape, selecting candidate protein building blocks
from a library and mapping them onto the shape and, finally,
testing the stability of the construct. Such a shape-based, part-
assembly strategy is conceptually similar to protein design
through the combinatorial assembly of building blocks. If the
conformational preferences of the building blocks are retained and
their interactions are favorable, the nanostructure will be
stable. The richness of the conformations, shapes and chemistries
of the protein building blocks suggests a broad range of potential
applications; at the same time, it also highlights their
complexity.
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The
Keck Friday Seminar*
schedule
for Fall 2006
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25-Aug
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Monte Pettitt, Chair,
KEC, Professor, Dept. of Chemistry, UH
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Overview of
Keck Center and GCC (5.520 Levin
Hall)
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1-Sept
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Labor
Day Weekend
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8-Sept
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Dr. Steen Pedersen,
Assoc. Professor, BCM, Dept. of Physiology and Biophysics
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Conformational
Regulation and Electrostatics of the Nicotine Acetylcholine
Receptor
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15-Sept
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Dr. C. J. Peters, M.D.,
Professor, Director for Biodefense, Center
for Biodefense and Emerging Infectious Diseases, UTMB
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Rift
Valley Fever: Adventures in Control and Vaccine Development.
***LIVE
FROM UTMB
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22-Sept
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Jacqueline
Northcut Waugh
President
and CEO,
BioHouston
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Reaching
for critical mass in Biotech (5.520
Levin Hall)
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29-Sept
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Dr. James Inglese, Dir,
Biomolocular Screening & Profiling, NIH, Nat’l Human Genome
Research Institute, Chemical Genomics Center
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Quantitative
High Throughput Screening: Discovery of Investigational Molecular
Probes through the Biological Activity Profiling of Chemical
Libraries
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6-Oct
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Luay
Nakhleh
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Non-treelike
Evolutionary Relationships
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13-Oct
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Keck
Annual Research Conference
https://cohesion.rice.edu/services/eventreg/?event=ARC6
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Edwin
Hornberger Conference Center, Texas Medical Center
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20-Oct
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ACS
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27-Oct
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Misha
Sherman, UTMB
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CryoEM
at UTMB ***LIVE
FROM UTMB
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3-Nov
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Marek
Kimmel, Professor, Statistics, Rice
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TBA
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10-Nov
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Ken Kennedy, Professor,
Rice University
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CANCELLED
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17-Nov
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Christy
Landes, Assistant Professor, Chemistry, University of Houston
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Single
molecule studies of disease-related biological processes: HIV
reverse transcription and herpes virus infection
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24-Nov
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Thanksgiving
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1-Dec
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Ruth Nussinov, Sr.
Prin. Scien, Nat’l Cancer Institute, Center for Cancer Res,
Computational Structural Biology Group
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Structure
by design: from single proteins and their building blocks to
nanostructures
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KECK/HAMP
Friday Seminars: http://xray.utmb.edu/keck
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Archived
Friday Seminar Webcasts Available:
http://cohesion.rice.edu/centersandinst/gcc/
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*Improved
clearer images: Now with POLYCOM's
DUAL STREAMING H.239 technology for clear
high-resolution slides plus video.
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