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Presents
the Friday Keck Center Teleconference*
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Computational
Modeling Identifies Morphologic Predictors of Tumor Invasion
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Vittorio
Cristini, Ph.D.,
Associate
Professor, School of Health Information Sciences, The U. Texas
Health Science Center at Houston
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4:00
pm Friday
March.
16th , 2007
(Refreshments
at 3:45)
5.521
Levin Hall
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Abstract: Mathematical
modeling based on first principles quantifies tumor growth's
dependence on interactions between a set of variables including
genomic instability producing variations in sub-tumor clonal
expansion and generating nutrient diffusion gradients and
demonstrates that these determinants of heterogeneity, and not
angiogenesis per se, conspire to produce the typical morphologic
patterns of infiltrative tumor boundaries in histopathology. We
demonstrate that heterogeneity in sub-tumor clonal expansion and
nutrient consumption drives migration and proliferation of the
emerging more aggressive clones up a nutrient concentration
gradient within and beyond the central tumor mass. This
heterogeneity and loss of cell adhesion trigger a gross
morphologic instability that leads to replacement of less
aggressive clones and separation of tumor cell strands or clusters
infiltrating into adjacent tissue. This model allows all variables
that characterize the biophysics of tumor growth to be considered
and could be applied to determine the probabilistic behavior of
tumors given their pathologic appearance.(
http://www.shis.uth.tmc.edu/news-1/shis-announces-new-faculty-appointment/
)
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The
Keck Friday Seminar*
schedule
for Spring 2007
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12-Jan
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Robert
Cox
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Functional
MRI
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19-Jan
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Ching Lau, Assoc Prof,
Pediatrics, Hematology/Oncology, BCM
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Novel
targets in pediatric brain tumors: from genomics to bedside
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26-Jan
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Irina
I. Serysheva
Baylor
College of Medicine
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Domain
Structure of RyR1 channel at Subnanometer Resolution
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2-Feb
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Poster winners from the
2006 Keck Annual Research Conference
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Matthew
Baker, Kexin Huang, & Jeffrey Reid
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9-Feb
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Mauro Ferrari,
Professor, Brown Foundation Institute of Molecular Medicine for
the Prevention of Human Diseases; Chairman, Dept. of Biomedical
Engineering, UTHSC-H
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Biomedical
Nonotechnology
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16-Feb
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Mike Mancini,
Associate Professor, Dept. of Molecular & Cellular Biology,
BCM
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Single cell
analyses of transcription using high throughput imaging
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23-Feb
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C. Thomas Caskey, Dir.
and COO, Institute for Molecular Medicine, UTHSC-H
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The Drug
Development Crisis: Efficiency and Safety
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2-Mar
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Jack Smith, Dean
& Professor, School of Health Information Sciences, UTHSC-H
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Issues
Related to Open Access and Clinical Data Repositories
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9-Mar
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Midterm
Recess
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16-Mar
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Vittorio Cristini,
Associate Professor, School of Health Information Sciences,
UTHSC-H
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Computational
modeling identifies morphologic predictors of tumor invasion
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23-Mar
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Margaret
Cheung, Assistant Prof, Physics, UH
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Life in a
crowd: macromolecular crowding and confinement effects on protein
interactions in living systems
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30-Mar
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Theodore
S. Jardetzky
Northwestern
University
Professor,
Biochemistry, Molecular Biology & Cell Biology
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TBA
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6-Apr
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Good
Friday
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13-Apr
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Keith Hodgson, Prof.
Chemistry, Stanford Synchrotron Radiation Laboratory, Stanford
University
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TBA
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20-Apr
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Stanley Lemon,
Dir, Institute for Human Infections and Immun; Professor, Internal
Medicine-Infectious Diseases, Microbiology, UTMB
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Interactions
of the hepatitis C virus RNA-dependent RNA polymerase NS5B with
the retinoblastoma tumor suppressor protein
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KECK/HAMP
Friday Seminars: http://xray.utmb.edu/keck
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Archived
Friday Seminar Webcasts Available:
http://cohesion.rice.edu/centersandinst/gcc/
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*Improved
clearer images: Now with POLYCOM's
DUAL STREAMING H.239 technology for clear
high-resolution slides plus video.
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