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Presents
the Friday Keck Center Teleconference*
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The
Paramyxovirus F Protein:
Structural
Insights into its Metastable Folding, Refolding and Membrane
Fusion Activity
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Ted
Jardetzky, Ph.D.,
Professor
of Biochemistry, Molecular Biology and Cell Biology, Northwestern
University
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4:00
pm Friday
March.
30th , 2007
(Refreshments
at 3:45)
5.521
Levin Hall
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Abstract: Enveloped
viruses, including HIV, influenza and the paramyxoviruses, have
evolved unusual glycoproteins that drive the fusion of viral and
cellular membranes, permitting entry of the viral genome into the
cell. For the paramyxoviruses, the fusion (F) protein catalyzes
this membrane merger and entry step and it has been postulated
that F undergoes substantial refolding during this process. We
have determined the structures of F in its two conformational
states, before and after membrane fusion, revealing profound
structural changes. We have also determined the structure of the
viral attachment protein, HN, in a complex with its receptor,
providing insights into HN\u2019s role in activating F-mediated
membrane fusion. The results have significant implications for
understanding the entry mechanisms of other viruses, for
developing improved protein-based vaccines and for designing novel
anti-viral agents.
(
http://www.biochem.northwestern.edu/ibis/faculty/jardetzky.htm
)
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The
Keck Friday Seminar*
schedule
for Spring 2007
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12-Jan
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Robert
Cox
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Functional
MRI
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19-Jan
|
Ching Lau, Assoc Prof,
Pediatrics, Hematology/Oncology, BCM
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Novel
targets in pediatric brain tumors: from genomics to bedside
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|
26-Jan
|
Irina
I. Serysheva
Baylor
College of Medicine
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Domain
Structure of RyR1 channel at Subnanometer Resolution
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2-Feb
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Poster winners from the
2006 Keck Annual Research Conference
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Matthew
Baker, Kexin Huang, & Jeffrey Reid
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9-Feb
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Mauro Ferrari,
Professor, Brown Foundation Institute of Molecular Medicine for
the Prevention of Human Diseases; Chairman, Dept. of Biomedical
Engineering, UTHSC-H
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Biomedical
Nonotechnology
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16-Feb
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Mike Mancini,
Associate Professor, Dept. of Molecular & Cellular Biology,
BCM
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Single cell
analyses of transcription using high throughput imaging
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23-Feb
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C. Thomas Caskey, Dir.
and COO, Institute for Molecular Medicine, UTHSC-H
|
The Drug
Development Crisis: Efficiency and Safety
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2-Mar
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Jack Smith, Dean
& Professor, School of Health Information Sciences, UTHSC-H
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Issues
Related to Open Access and Clinical Data Repositories
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9-Mar
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Midterm
Recess
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16-Mar
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Vittorio Cristini,
Associate Professor, School of Health Information Sciences,
UTHSC-H
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Computational
modeling identifies morphologic predictors of tumor invasion
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23-Mar
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Margaret
Cheung, Assistant Prof, Physics, UH
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Life in a
crowd: macromolecular crowding and confinement effects on protein
interactions in living systems
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30-Mar
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Theodore
S. Jardetzky
Northwestern
University
Professor,
Biochemistry, Molecular Biology & Cell Biology
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Structural
Insights into the Metastable Folding, Refolding and Membrane
Fusion Activity of the Paramyxovirus F Protein.
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6-Apr
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Good
Friday
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13-Apr
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Keith Hodgson, Prof.
Chemistry, Stanford Synchrotron Radiation Laboratory, Stanford
University
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TBA
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20-Apr
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Stanley Lemon,
Dir, Institute for Human Infections and Immun; Professor, Internal
Medicine-Infectious Diseases, Microbiology, UTMB
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Interactions
of the hepatitis C virus RNA-dependent RNA polymerase NS5B with
the retinoblastoma tumor suppressor protein
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KECK/HAMP
Friday Seminars: http://xray.utmb.edu/keck
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Archived
Friday Seminar Webcasts Available:
http://cohesion.rice.edu/centersandinst/gcc/
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*Improved
clearer images: Now with POLYCOM's
DUAL STREAMING H.239 technology for clear
high-resolution slides plus video.
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