Presents the Friday Keck Center Teleconference*
Dissection and Redesign of a Protein-Protein Interaction Interface
Timothy Palzkill, Ph.D.,
Professor of Virology & Microbiology
Baylor College of Medicine
4:00 pm Friday
Sept. 7th , 2007
(Refreshments at 3:45)
5.521 Levin Hall
Abstract: Protein-protein interactions are critical for many biological processes. An understanding of the molecular basis of these interactions is required to engineer novel protein-protein interactions or design drugs that target these interactions. Beta-lactamase inhibitory protein (BLIP) is a 17 kDa protein that binds and inhibits beta-lactamases with a wide range of affinities. The BLIP-beta-lactamase interaction is being used as a model system to understand the determinants of binding affinity in the interface and to explore how the specificity of protein-protein interactions is controlled. ( http://scbmb.bcm.tmc.edu/people/gcc_faculty_116 )
