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Presents
the Friday Keck Center Teleconference*
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Neurotransmitter
transporters: A dance of
domains and substrates
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Susan
Amara, Ph.D.,
University
of Pittsburg School of Medicine
Thomas
Detre Professor and Chair, Department of Neuroscience
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4:00
pm Friday
Jan.
18th
, 2008
(Refreshments
at 3:45)
5.521
Levin Hall
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Abstract:
Neurotransmitter transporters present at the plasma membrane
contribute to the clearance and recycling of neurotransmitters and
have a profound impact on the extent of receptor activation during
neuronal signaling. In addition to their role in neurotransmitter
clearance, these carriers are the primary targets for
psychostimulant drugs of abuse, therapeutic antidepressants and
other drugs used to treat brain disorders. Our research efforts
have focused on the structure, regulation and cellular physiology
of two families of sodium-dependent neurotransmitter transporters,
the biogenic amine and the excitatory amino acid carriers.
Although these transporters have their primary role in
neurotransmitter clearance, members of both families also display
a ligand-gated chloride channel activity that can regulate
neuronal excitability and neurotransmitter release. This lecture
will consider neurotransmitter transporter functions and their
role as drug targets and will present results from structural,
electrophysiological and cell biological studies aimed at defining
the relationships between neurotransmitter transporter structure,
substrate transport, and ion permeation.
(http://www.neurobio.pitt.edu/faculty/amara.htm)
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The
Keck Friday Seminar*
Schedule
for Spring 2008
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11-Jan
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Monte
Pettitt, Hugh Roy and Lille Cranz Cullen Distinguished Professor
of Chemistry, University of Houston
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The
Hydrophobic Effect: What it is and what it is not
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18-Jan
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Susan
Amara, Thomas Detre Professor and Chair, Dept. of Neuroscience,
Univ. of Pittsburgh School of Medicine
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Neurotransmitter
transporters: A dance of domains and substrates
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25-Jan
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Keck
Annual Research Conference Poster Winners, Part 1
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Constantinou,
Mankiewicz, Ofek, Parikh, Zhang
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1-Feb
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Jennifer
L. West, Isabel C. Cameron Professor of Bioengineering, Rice
University
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TBA
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8-Feb
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No
Seminar
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15-Feb
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Keck
Annual Research Conference Poster Winners, Part 2
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Fuson,
Heyd, Malmstrom, Marsh, Ostrowski
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22-Feb
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TBA
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TBA
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29-Feb
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Robert
Powers, Assistant Professor of Chemistry, University of Nebraska
at Lincoln
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Functional
and Therapeutic Analysis of Novel Proteins by NMR
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7-Mar
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No
Seminar
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14-Mar
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TBA
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TBA
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21-Mar
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No
Seminar
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28-Mar
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Xiaodong
Zhang, Reader in Molecular Structure and Function, Imperial
College, London, UK
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TBA
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4-Apr
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Richard
Gibbs, Wofford Cain Professor, Department of Molecular and Human
Genetics, Baylor College of Medicine
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TBA
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11-Apr
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Jin
Wang, Assistant Professor of Chemistry and Physics, State
University of New York at Stoney Brook
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TBA
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18-Apr
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Pamela
A. Silver, Professor of Systems Biology, Harvard Medical School
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TBA
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KECK/HAMP
Friday Seminars: http://xray.utmb.edu/keck
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Archived
Friday Seminar Webcasts Available:
http://cohesion.rice.edu/centersandinst/gcc/
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*Improved
clearer images: Now with POLYCOM's
DUAL STREAMING H.239 technology for clear
high-resolution slides plus video.
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