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Presents
the Friday Keck Center Teleconference*
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Single
Neuron Computation: Achieving
radical dimension reduction without trimming the tree
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Steven
J. Cox, Ph.D.,
Professor
of Computational and Applied Mathematics, Rice University
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4:00
pm Friday
April
4th
, 2008
5.521
Levin Hall
(Refreshments
at 3:45)
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Abstract:
Each of your hundred billion neurons is a formidable computational
unit. For, each neuron distributes its ionic and synaptic
conductances in a manner that facilitates an incredible variety of
input/output functions. Although we have long had detailed models
of individual cells, their level of detail carries a computational
cost that prohibits their use in simulations of networks of
"realistic" size. As a result, nearly every large scale
simulation presumes cells with radically compromised dendritic
trees. Namely, cells with one or at most two independent
compartments. Such tree trimming irretrievably ignores the
sculpting of synaptic input as it makes its way to the site of
action potential initiation. We here present and test a method for
reducing the dimension of the cell model (from 5000 to 5) while
retaining the cell's rich synaptic input structure. We show that
our method dramatically accelerates investigations of dendritic
democratization and resonance and we speculate on its
applicability to investigations of large-scale network activity.
(http://cohesion.rice.edu/)
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The
Keck Friday Seminar*
Schedule
for Spring 2008
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11-Jan
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Monte
Pettitt, Hugh Roy and Lille Cranz Cullen Distinguished Professor
of Chemistry, University of Houston
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The
Hydrophobic Effect: What it is and what it is not
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18-Jan
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Susan
Amara, Thomas Detre Professor and Chair, Dept. of Neuroscience,
Univ. of Pittsburgh School of Medicine
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Neurotransmitter
transporters: A dance of domains and substrates
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25-Jan
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Keck
Annual Research Conference Poster Winners, Part 1
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Constantinou,
Mankiewicz, Ofek, Parikh, Zhang
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1-Feb
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Jennifer
L. West, Isabel C. Cameron Professor of Bioengineering, Rice
University
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Biomimetic
Strategies in Tissue Engineering and Regenerative Medicine
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8-Feb
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No
Seminar
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15-Feb
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Keck
Annual Research Conference Poster Winners, Part 2
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Fuson,
Heyd, Malmstrom, Marsh, Ostrowski
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22-Feb
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Jonas
S. Almeida, Professor of Bioinformatics and Computational Biology
UT
M. D. Anderson Cancer Center
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Integrative
Bioinformatics - a lot of coding or a lot of talking?
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29-Feb
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Robert
Powers, Assistant Professor of Chemistry, University of Nebraska
at Lincoln
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Functional
and Therapeutic Analysis of Novel Proteins by NMR
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7-Mar
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No
Seminar
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14-Mar
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Werner
Braun, UTMB
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Algorithms
and Software Tools for the Prediction of Allergenicity
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21-Mar
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No
Seminar
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28-Mar
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Xiaodong
Zhang, Reader in Molecular Structure and Function, Imperial
College, London, UK
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Bacterial
Gene Activation via AAA+ sigma54 Activators
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4-Apr
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Steven
J. Cox
Professor
of Computational and Applied Mathematics, Rice University
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Single
Neuron Computation: Achieving radical dimension reduction without
trimming the tree
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11-Apr
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Jin
Wang, Assistant Professor of Chemistry and Physics, State
University of New York at Stoney Brook
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TBA
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18-Apr
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E.
M. Sevick
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TBA
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KECK/HAMP
Friday Seminars: http://xray.utmb.edu/keck
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Archived
Friday Seminar Webcasts Available:
http://cohesion.rice.edu/centersandinst/gcc/
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*Improved
clearer images: Now with POLYCOM's
DUAL STREAMING H.239 technology for clear
high-resolution slides plus video.
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